Hematology Medicine 2023

Which statement regarding blood products is inaccurate?

Which is the worst-case scenario that best suits Rh incompatibility?

 In which organ is mucosa-associated lymphoid tissue absent?

Which process is unrelated to anemia?

Which of the following statements regarding the Reed-Sternberg cell is NOT true?

Which of the following molecules is involved in platelet adhesion?

 Bernard-Soulier syndrome is caused by abnormalities in which of the following molecules?

Which the following tests is NOT used in the diagnosis of DVT?

Which of the types of cell listed below is characteristically found in vitamin B12 deficiency?

Which of the following is NOT considered a myeloproliferative disorder?

Which of the following agents is NOT usually used to treat patients with multiple myeloma?

Which B-cell receptor signalling pathway is blocked in order to inhibit the proliferation signals produced by tumor cells?

 Which of the following is not usually found in the spleen?

A gel technique is set up to assess the donors’ blood group. A drop of anticoagulation blood is added to the A, B, and anti-D gel columns. After centrifugation, a red cell button is observed on the top of gel column A, but at the bottom of the gel columns of B and anti-D. What is the blood group of the patient?

Which method would be excluded from a list of ways through which bacteria are identified for phagocytosis by neutrophils?

In which disease do clients have a blood picture of microcytic hypochromic anemia?

Which of the following statements is TRUE regarding the staging of lymphoma?

Which ion is required for the platelet adhesion reaction?

What levels of factor VIII are seen in severe haemophilia A?

Which of the following statements about thalassemia is FALSE ?

Which of the following statements accurately describes the pathogenesis of pernicious anemia?

Which of the following genes is most commonly found to be mutated in myeloproliferative disorders?

Which of the following is used in the diagnosis of aplastic anemia?

Which of the following is NOT associated with chronic myeloid leukemia?

Which factors are exclusion criteria for a person to donate blood? Select all that apply.

Which condition is best treated with fresh frozen plasma?

Which granule in the neutrophil is an example of a tertiary granule?

What are the most likely clinical problems to arise in a client with a low white cell count and a raised platelet count?

Which of the following viruses is implicated in a subset of cases of Hodgkin lymphoma?

Which of the following factors does not effect aPTT?

Which of the following clotting factors is deficient in hemophilia B?

Which of the following is NOT a plasminogen activator?

Which of the following red blood cell parameters is increased due to the presence of reticulocytes in hemolytic anemia?

What role does the JAK2 protein play within hemopoietic cells?

Which of the following is NOT used in the treatment of aplastic anemia?

Which of the following is a characteristic feature of the blood smear in chronic lymphocytic leukemia?

Which of the following is correct regarding platelets after a blood sample is centrifuged?

 Which antibodies cause immediate lysis of the blood cells when there is a mismatch transfusion?

A 10-year-old child has been diagnosed with a parasitic infection. Which cells are commonly increased in the peripheral blood in this situation?

A client has leukemia that developed rapidly over 2 months and led to a proliferation of lymphoblasts. Which subtype of leukemia does the client most likely have?

Which of the following is required to make a definitive diagnosis of Hodgkin lymphoma?

Which of the following factors is now thought to be critical to the initiation of coagulation?

Which of the following types of Von Willebrand factor disease does not have vWF multimers?

Which of the following is an ADP receptor antagonist?

Below what approximate RBC lifespan can anemia be precipitated?

In patients with essential thrombocytosis who do not have a JAK2 mutation, what gene is most commonly mutated?

Which one of the following drugs is NOT used in the treatment of acute lymphoblastic leukemia?

What causes the characteristic appearance of smudge cells?

What is the approximate amount of whole blood typically given by a donor at a single time?

 Which statement regarding adult hemoglobin (HbA) is inaccurate?

Which group reflects the correct order from the least mature to the most mature cell in the myeloid series?

At what count does neutropenia become life-threatening?

Which of the following cell types gives rise to the Reed-Sternberg cell?

A 24-year-old woman notices bleeding from a venipuncture site during a difficult childbirth. Full blood count shows the platelet count has fallen from the normal value to 30 over 6 hours. Which of the following is the most likely diagnosis?

With which of the following clotting factors is Von Willebrand disease associated?

Which of the following plays a role in the lysis of fibrin?

Which type of bilirubin will be increased in the blood of a patient with hemolytic anemia?

Which of the following is NOT a common sign or symptom of polycythemia vera?

Which of these statements is NOT TRUE regarding acute myeloid leukemia?

Which of the following statements regarding the Reed-Sternberg cell is NOT true?

Which disease is excluded from screening before blood donation?

Which cell can ingest bacteria, migrate into tissues, and play an important role in initiating immune responses?

Which symptom best suggests a white cell neoplastic disorder?

Which type of leukemia/lymphoma is most commonly seen in clients older than 60 years?

Which of the following statements about non-Hodgkin lymphomas is true?

Which ONE of these is a primary disorder of the blood vessel?

Which of the following is NOT a common risk factor for arterial thrombosis?

Which parameter measured on a a peripheral smear is used in the classification of anemia?

 Which of the following anemias is 5q syndrome associated with?

Which of the following is NOT part of the treatment of polycythemia vera?

BCR-ABL gene fusion is mostly involved in which of the following conditions?

Which of these statements regarding blood is NOT TRUE?

Which method is used for the screening of donor blood?

Which types of heme molecules does an adult have in the erythrocyte?

Which of the following can be a manifestation of a platelet disorder?

Which cells are diagnostic of Hodgkin lymphoma?

The most common subtype of high-grade non-Hodgkin lymphoma is…?

Which of the following results in the release of granules from platelets?

Which of the following inherited thrombophilias is seen in approximately 3% of the population?

Where is most of the body’s iron contained?

Which of the following statements is FALSE regarding myelodysplastic syndrome?

Which of the following is part of the treatment protocol for essential thrombocytosis?

In which age group is acute lymphoblastic leukemia commonly seen?

Which of the following cells remain in the circulation for 120 days?

Which substance is used in the cross-matching of blood from the donor and the client?

Which statement regarding the oxygen dissociation curve is inaccurate?

What unit of measure is used for hemoglobin?

Which condition is a hematological disorder in which active bone marrow produces dysfunctional cells?

Which of the following investigations is helpful in staging patients with non-Hodgkin lymphoma?

 Of the clotting study results shown below, which is most likely to belong a patient with Hemophilia?

A 24-year-old woman in the 6th week of an uncomplicated pregnancy develops a deep vein thrombus (DVT). Which of the following is the appropriate treatment?

Which form of iron is most readily absorbed by the intestinal cells?

Which of the following molecules anchor the spectrin molecule?

What is the pathology causing illness in primary myelofibrosis?

 Presence of which of the following genetic abnormalities is a bad prognostic factor for acute lymphoblastic leukemia?

Which of the following cells remain at the bottom of the tube after centrifugation?

Which antibody is naturally occurring?

What is the role of hemoglobin in carbon dioxide transport?

 Which of the following test can be performed in the emergency department, as a fast, portable, real-time assessment of abdominal anatomy?

Which effects are expected in patients with megaloblastic anemia?

 Which of the following is the effect of the t(14:18) translocation carried by tumoral cells in follicular lymphoma?

Which of the following is strongly associated with PT prolongation?

Which of the following statements concerning inherited thrombophila is NOT true?

Which aminoacid is involved in the synthesis of heme?

Which of the following does NOT cause an oxidative stress that could precipitate a G6PD hemolytic crisis?

Which of the following finding is NOT suggestive of the diagnosis of multiple myeloma?

Which of the following is a common site for relapse of acute lymphocytic leukemia?

 Which of the following statements are TRUE regarding blood components?

Which cells in the blood have the capacity to directly kill virus-infected cells?

Which of the following statements is correct regarding magnetic resonance imaging (MRI)?

Which of the following is seen in patients with acute blood loss?

What are PET scans used for in patients with Hodgkin lymphoma?

A 40-year-old female presents with bone pain and gum bleeding. Her CBC reveals leukocytosis. The patient has both a prolonged PT and aPTT with a low fibrinogen. What is the most likely cause of her presentation?

Which of the following is a physical method of preventing venous thrombi from migrating to the lungs?

Which of the following is found in higher amounts in beta-thalassemia major?

Which of the following describes the etiology of hemolytic crises in G6PD deficiency?

Which inherited disorder is MOST likely present in a child with a CBC showing: Hb 70 g/l, WBC 0.2, and platelets 30?

Which of the following cells is is seen in myeloid leukemia on a bone marrow aspirate?

 Which of the following progenitors is the NK cell derived from?

After 30 minutes of transfusion, a client developed breathlessness and low blood pressure. Which blood group antigen is most likely to be involved in this clinical scenario?

Which structure is involved in the movement of lymphocytes into the lymph node?

Which radiolabeled material is used in a PET scan for highlighting tumor metastasis?

Which complication is associated with polycythemia?

Which ONE of these is NOT true concerning platelets and their function?

 Which of the following is calculated as a ratio of measured prothrombin time to a standard value determined in the laboratory?

To what class of molecules does heparin belong to?

Which of the following conditions will result in a mild increase in HbA2, mild decrease in HbA1, a normal fetal hemoglobin, and absent Hb H on electrophoresis ?

 Which of the following hemoglobinopathies is thought to convey some protection against malaria?

Which of the following statement is true with regards to acute leukemia?

AML seen with which of the following chromosomal translocations is known to be associated with disseminated intravascular coagulation?

Which of the following interleukins do eosinophils require during their differentiation from eosinophil progenitors?

Which is not a complication of regular red cell transfusions?

Which cell is a T-cell lymphocyte marker?

When a client has 101 fl, what are the blood cells considered to be?

Which factor causes EPO to be normal or decreased although there is an increase of the red cells?

Which of the following agents are used in the treatment of symptomatic stage III follicular lymphoma?

What type of antibodies are directed against platelets in immune-mediated thrombocytopenia?

Which Vitamin is antagonized by Warfarin?

What is the characteristic radiological sign of thalassemia on skull X-Ray?

What is the temperature at which antibodies bind to red cells in warm autoimmune hemolytic anemia?

 What cell types are predominantly involved in acute leukemia?

Which of the following is classically associated with all acute leukemias?

Which cells do the monocytes become when they enter tissue?

Which antibodies are present in the serum of a patient with A-positive blood?

 Platelet transfusion is indicated when the platelet count falls below which value?

 Which factor is unrelated to the cause of leukocytosis?

Which cells are clonally increased in myeloma?

 Production of what paraprotein is characteristic of lymphoplasmacytic lymphoma?

Which of the following is deficient in thrombotic thrombocytopenic purpura?

Which of the following is NOT a route of administration of heparin?

What is the common complication of treatment of thalassemia?

Which of the following is the treatment of choice in patients with sickle cell anemia?

Which of the following is the most common malignant disease in children?

Which of the following drugs used in the treatment of acute leukemia causes microtubule arrest and thus prevents the further division of cells?

 Which of the following cells are only cytoplasmic fragments and do not contain nuclei?

Which genes are translated into the Rh antigens?

What blood product has the shortest shelf life?

Which anticoagulant is used for counting blood cells?

 Which factor causes a functional defect of platelets?

 Which of the following populations has an increased risk of developing Burkitt lymphoma?

Which of the following is a typical finding of deep vein thrombosis?

Which of the following is the enzyme required for conversion of inactive coagulation factors II, VII, IX, and X into active factors?

Where does the body sequester iron in patients with chronic infections?

Which of the following findings would you expect in a patient with primary polycythemia?

Which of the following findings, commonly seen in the peripheral blood film of patients with multiple myeloma, is due to increased antibody levels in the blood?

Which of the following is the MOST common presentation of chronic lymphoid leukemia?

Which of the following cells develop granules containing toxic enzymes in their cytoplasm?

Which of the following methods is the most useful for preventing hemolytic disease of the newborn?

What is the correct description of a neutrophil count of 20 x 10 to the power of 9/L in blood?

 Which site is common place for a bone marrow biopsy to be performed?

Which condition is a symptom of thrombocytosis?

Which of the following is a complication of lymphoplasmacytic lymphoma?

Which of the following statements is FALSE regarding thrombotic thrombocytopenic purpura?

Which of the following drugs is a factor IIa inhibitor?

Which of the following is given to a patient with chronic renal failure to stimulate red blood cell production?

Which gene is commonly associated with polycythemia vera?

Which of the following techniques can be used to detect paraproteins in the blood of a patient with multiple myeloma?

What is the treatment for chronic lymphocytic leukemia?

 What area of the bone houses hemopoietic stem cells?

 Which moiety is modified in A and B blood groups so that it gives each blood group a unique classification?